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The NEURON Network has launched a joint transnational call for projects on 'Cerebrovascular diseases including small vessel and brain barrier dysfunction'.

The 'Network of European Funding for Neuroscience Research' (NEURON) aims at coordinating and optimising research efforts and funding programmes of its partner countries in the field of mental, neurological and sensory disorders.

With the newly launched call, ERA-NET NEURON wishes to facilitate multinational, collaborative research projects that will address important translational questions in the areas of stroke and other cerebrovascular diseases including small vessels disease (CSVD) and the dysfunction of brain barriers. The present call is aimed at funding preclinical and clinical research addressing the pathophysiology and therapeutic developments for stroke and other cerebrovascular diseases.

Proposals relating CSVD and the dysfunction of brain barriers to cerebrovascular disease are encouraged. Research areas may cover a broad range of aspects associated with cerebrovascular disease such as genetic, epigenetic, molecular mechanisms of disease. Neuroinflammatory processes often play an important role in cerebrovascular diseases and are included in the call. The development of preventive, diagnostic or therapeutic approaches including pharmacological studies (e.g. on drug target identification) and technological developments based on pathophysiological mechanisms are within the scope of the call.

The call will accept research proposals ranging from investigations into the basic mechanisms of cerebrovascular disease and brain barrier dysfunctions through to proof-of-concept clinical studies in humans. The NEURON funding organisations particularly wish to promote multidisciplinary work and translational research proposals that combine basic, clinical and/or technological approaches.

Research proposals should cover at least one of the following areas:

  • Fundamental research addressing the pathogenesis, aetiology, progression, treatment and prevention of cerebrovascular diseases including CSVD as well as basic research to elucidate the role of brain barriers on cerebrovascular diseases. This may include the development of innovative or shared resources and technologies including computational and statistical tools, as considered of relevance in the context of this call.
  • Clinical research to develop novel strategies for prevention (including secondary prevention), diagnosis, patient stratification, therapy and/or rehabilitation for cerebrovascular diseases

Research on neurodegenerative disorders addressed by the EU Joint Programme - Neurodegenerative Disease Research (JPND), and proposals focused primarily on cardiological or metabolic causes of or comorbidities (i.e. diabetes, obesity, Covid-19/long Covid) with cerebrovascular diseases are excluded from this call.

Pre-proposals must be submitted no later than 14:00 CET on 8 March 2022 via the electronic submission tool.

Full proposals must be submitted no later than 14:00 CEST on 28 June 2022 via the electronic submission tool.